logo-tissuegnostics

TissueGnostics is a solution provider for Precision Medicine and provides fully integrated cutting-edge tissue cytometers including a multitude of configurations from multispectral & high-throughput scanning to contextual tissue cytometry. The goal of TissueGnostics is to bring the same type of phenotypical analysis of single cells from Flow Cytometry into tissue context. For more infomation about TissueGnostics and Precision Medicine, please follow the link to the dossier "FIGHT CANCER! The age of precision medicine has dawned".

MULTISPECTRAL IMAGING

TissueFAXS SPECTRA

TissueFAXS SPECTRA
Multispectral Tissue Cytometer

TissueFAXS SPECTRA systems provide Multispectral Imaging, Spectral Unmixing and Contextual Tissue Cytometry Image Analysis on the basis of the TissueFAXS platform.

SPECTRA technology is available on any TissueFAXS system configuration, be it upright, inverted, TissueFAXS Histo, TissueFAXS Fluo, TissueFAXS PLUS or Slide Loader-based (SL).

TissueFAXS SPECTRA
Multispectral Tissue Cytometer

TissueFAXS SPECTRA systems provide Multispectral Imaging, Spectral Unmixing and Contextual Tissue Cytometry Image Analysis on the basis of the TissueFAXS platform.

SPECTRA technology is available on any TissueFAXS system configuration, be it upright, inverted, TissueFAXS Histo, TissueFAXS Fluo, TissueFAXS PLUS or Slide Loader-based (SL).

TissueFAXS SPECTRA
UNIQUE FEATURES

  • Multispectral fluorescence imaging
  • Spectral unmixing function
  • Brightfield imaging (optional)
  • 8 slides scanning
  • Slide ID scanner
  • Quantitative image analysis option
TissueFAXS_Spectra_Inverted
TissueFAXS_Spectra_upright

Technology

TissueFAXS SPECTRA is based on a liquid crystal tunable filter and the spectral unmixing engine of StrataQuest analysis software. Liquid crystal tunable filters are optical filters that use electronically controlled liquid crystal elements to transmit a selectable wavelength of light and exclude others. They can be tuned to specific wavelengths within the visible spectrum at high speeds. This makes them ideal for a quick building of the lambda stacks (a.k.a "Image Cubes" or "Spectral Cubes"), which then can be used for spectral unmixing.

This permits the separation of multiple colors in both, brightfield and fluorescence. The following graphic shows the process from building the lambda stack to color deconvolution via the StrataQuest spectral unmixing engine. The result is four greyscale channel images corresponding to the four unmixed colours and an overlay image analogous to a fluorescence overlay image.

Contextual Tissue Cytometry

The separated channel images can then easily be used for contextual tissue cytometry analysis as provided by StrataQuest. This technology perfectly matches a current trend to look at multiple markers in parallel in order to better understand interactions among and between different cell types and cellular subpopulations.

PROPERTIES

Design: Modular (Microscope, Cameras, Light-source, PC with 2 Monitors)

Microscopy mode: Multi Spectral Fluorescence, Brightfield

Compatible Slide Formats: All standard and over-sized slides

Slide Capacity: 8

Objectives: Up to 7 Objectives (2.5-100x)

FL-Channels: 8

Camera: CMOS Camera (8/10-bit, 4.2 Megapixel, Color). sCMOS Camera (8/16-bit, 4 Megapixel, Monochrome)

Light Source: Solid-state light engine

Tissue Microarray (TMA): YES

Image Analysis Software: QUEST line (Algorithms for tissue detection, area measurement, scattergrams for cells and many more)

Supported Image Formats: TissueFAXS, OME-TIFF, TIFF, JPEG, BMP, PNG

Viewer: Integrated, stand-alone freeware

TGLogowhite

REFERENCES

TissueGnostics has over 1,500 scientific reference publications

Learn more ›

REFERENCES

TissueGnostics has over 1,500 scientific reference publications

Learn more ›

Need more information / Questions?

Need more information / Questions?

Please contact us by phone or email:

Freephone 0800 724 633

info@scienze.nz

Or use the contact form below:

Please enter your name.
Please enter a message.

For Greater Productivity & Insights

For Greater Productivity & Insights

Copyright © 2020, Scienze. All rights reserved.