Aurora500

Ion Channel Readers 8100

ICR-8000-reflection-crop-4x5-1-300x300

ICR 8100- Primary Drug Screening Technology

Aurora Biomed’s Ion Channel Readers (ICR) combine the versatility, precision, and sensitivity of atomic absorption spectroscopy (AAS) with our patented microsampling process and liquid handling technologies, creating a high-throughput screening solution for ion channel researchers that fills gaps, which automated patch-clamp cannot. The ICR 8100 is a more affordable, mid-throughput ion channel screening system that is compact enough for the benchtop while retaining broad utility.

The ICR 8100 can be used to assess both voltage-gated (hERG, BK/SK, Kv1.1, 1.4, 1.5, KCNQ, 2P, etc.) and ligand-gated (KATP, nAChR, etc.) ion channels, as well as ion pumps and transporters (e.g., Na+/K+-ATPase), allowing researchers to accelerate drug development for the treatment and prevention of diseases associated with these key membrane transport proteins.

Current applications include the evaluation of the Cation-Chloride Cotransporter (CCC), a critical component of neuronal chloride homeostasis that is an essential regulator of cell volume and neuronal excitability. Because CCCs are electroneutral, their activity cannot be measured using automated patch-clamp techniques. The ICR 8100 is able to obtain high throughput activity measurements for these and other channels and transporters by measuring the absolute concentrations of cytosolic and extracellular ions, a technique that is independent of, and complimentary to, methods that rely on voltage manipulation.

Features & Benefits

  • Programmable and automated solution for up to 5000 wells/day
  • Automatic dilution, calibration and cleaning
  • Adaptable to existing robotic automation
  • Sample dilution not required
  • High sensitivity
  • On-line dilution
  • Eliminates quenching effects associated with fluorescence
  • Removes need to work with hazardous radioisotopes
  • Avoids work restrictions posed by Rb’s short half-life
  • Ideal for hERG channel assays
  • Can assess both electrogenic and electroneutral transporters

Specifications

  • Medium Throughput: Up to 5000 wells/day
  • Single Channel: Measures 1 sample at a time
  • Minimum sample volume: 50 µl
  • Accommodation: 96/384-well microplates
  • Footprint: H.67 cm X W.55 cm X D.37 cm
  • Fuel Source: Acetylene / Compressed Air
  • Options: Plate Stacker / Barcode Reader
  • Sensitivity: 0.05 ppm detection limit
  • Precision: < 5% CV

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