Aurora500

Ion Channel Readers 12000

ICR12000_reflection-4x5-crop-1-300x300

ICR 12000- High-throughput Drug Screening Technology

The ICR 12000 is designed for ultra-high throughput ion channel screening of compound libraries, incorporating multi-channel sampling and enhanced automation features. Based upon the versatility, precision, and sensitivity of Aurora Biomed’s atomic absorption spectroscopy (AAS) instruments, the ICR 12000 is suitable for both ligand-gated and voltage-gated ion channels using cell-based flux assays. With the robustness of Aurora Biomed’s ICR technology, the reader offers high sensitivity for both electrogenic and electroneutral channels and transporters. The incredible 60,000 sample per day throughput of the ICR 12000 enables ion channel researchers to access compound QT liability early in the drug discovery process.

Features & Benefits

  • Programmable and automated solution for up to 60,000 wells/day
  • Automatic dilution, calibration and cleaning
  • Integrated plate stacker & bar code reader
  • Sample dilution not required
  • High sensitivity
  • On-line dilution
  • Eliminates quenching effects associated with fluorescence
  • Removes need to work with hazardous radioisotopes
  • Avoids work restrictions posed by Rb’s short half-life
  • Ideal for hERG channel assays
  • Can assess both electrogenic and electroneutral transporters

Specifications

  • Medium Throughput: Up to 60,000 wells/day
  • 12 Channel: Measures 12 sample at a time
  • Minimum sample volume: 20 µl
  • Accommodation: 96/384-well microplates
  • Footprint: H.120 cm X W.95 cm X D.37 cm
  • Fuel Source: Acetylene / Compressed Air
  • Options: Plate Stacker / Barcode Reader
  • Sensitivity: 0.05 ppm detection limit
  • Precision: < 5% CV

Independently Validated

Researchers from Roche performed high-throughput screening campaigns for modulators of a cation-chloride co-transporter using the ICR 12000.

Download their poster from the 2016 Ion Channel Summit to see how Roche developed high throughput rubidium (Rb+) uptake assay for measuring NKCC1 function and subsequently screened 1.2 million compounds using Aurora’s ICR 12000.

Development of a non-radioactive Rubidium flux assay to carry out high-throughput screening for electroneutral NKCC1 ion transporter.

Download the publication of the collaboration study with Roche to develop a high throughput rubidium (Rb+) flux assay for measuring electroneutral NKCC1 activity.

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